Peer-reviewed publications
査読付論文

  1. Casco-Robles, R.M., Watanabe, A., Eto, K., Takeshima, K., Obata, S., Kinoshita, T., Ariizumi, T., Nakatani, K., Nakada, T., Tsonis, P.A., Casco-Robles, M.M., Sakurai, K., Yahata, K., Maruo, F., Toyama, F.* and Chiba, C.* (2018) Novel erythrocyte clumps revealed by an orphan gene Newtic1 in circulating blood and regenerating limbs of the adult newt . Scientific Reports 8: 7455. DOI: 10.1038/s41598-018-25867-x.
  2. Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.* (2017) Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster. Toxicon 137: 78-82. DOI: 10.1016/j.toxicon.2017.07.016
  3. Yasumuro, H., Sakurai, K., Toyama, F., Maruo, F. and Chiba, C.* (2017) Implications of a multi-step trigger of retinal regeneration in the adult newt. Biomedicines 2017, 5, 25. DOI: 10.3390/biomedicines5020025
  4. Casco-Robles, M.M.*, Islam, M.R., Inami, W., Tanaka, H.V., Kunahong, A., Yasumuro, H., Hanzawa, S., Casco-Robles R.M., Toyama, F., Maruo, F. and Chiba, C.* (2016) Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts. Scientific Reports 6:33761. DOI: 10.1038/srep333761
  5. Tanaka, H.V., Ng, N.C.Y., Yu, Z.Y., Casco-Robles, M.M., Maruo, F., Tsonis, P.A.* and Chiba, C.* (2016) A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts. Nature Communications. 7:11069. DOI: 10.1038/ncomms11069
  6. Endo, Y.*, Toyama, F., Chiba, C., Mori, H. and Shoji, K. (2016) Memory Efficient de novo Assembly Algorithm using Disk Streaming of K-mers. Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016). Vol.3, pp.266-271. ISBN: 978-989-758-170-0.
  7. Inami, W., Islam. M.R., Nakamura, K., Yoshikawa, T., Yasumuro, H., Casco-Robles, M.M., Toyama, F., Maruo, F. and Chiba, C.* (2016) Expression of two classes of Pax6 transcripts in reprogramming retinal pigment epithelium cells of the adult newt. Zool. Sci. 33: 21-30. DOI: 10.2108/zs150111.
  8. Sousounis, K., Qi, F., Yadav, M.C., Millan, J.L., Toyama, F., Chiba, C., Eguchi, Y., Eguchi, G. and Tsonis, P.A.* (2015) A robust transcriptional program in newts undergoing multiple events of lens regeneration. eLife 2015;10.7554/eLife.09594. DOI: http://dx.doi.org/10.7554/eLife.09594
  9. Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.* (2015) Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS. Toxicon 101: 101-105. DOI: 10.1016/j.toxicon.2015.05.008
  10. Endo, Y.*, Toyama, F., Chiba, C., Mori, H. and Shoji, K. (2015) A memory efficient short read de novo assembly algorithm. IPSJ Transactions on Bioinformatics 8: 2-8. DOI: http://doi.org/10.2197/ipsjtbio.8.2
  11. Casco-Robles, M.M.*, Miura, T. and Chiba, C*. (2015) The newt (Cynops pyrrhogaster) RPE65 promoter: molecular cloning, characterization and functional analysis. Transgenic Res. 24: 463-473. DOI: 10.​1007/​s11248-014-9857-1
  12. Nakamura, K., Islam, M.R., Takayanagi, M., Yasumuro, H., Inami, W., Kunahong, A., Casco-Robles, R.M., Toyama, F*. and Chiba, C*. (2014) A transcriptome for the study of early processes of retinal regeneration in the adult newt, Cynops pyrrhogaster. PLoS One 9, e109831. DOI: 10.1371/journal.pone.0109831
  13. Islam, M.R., Nakamura, K., Casco-Robles, M.M., Kunahong, A., Inami, W., Toyama, F., Maruo, F. and Chiba, C*. (2014) The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration. Scientific Reports 4:6043. DOI: 10.1038/srep06043
  14. Endo, Y., Toyama, F*., Chiba, C., Mori, H. and Shoji, K. (2014) De novo short read assembly algorithm with low memory usage. Proceeding of the International Conference on Bioinformatics Models, Methods and Algorithms. 215-220. DOI: 10.5220/0004881002150220
  15. Chiba, C*. (2014) The retinal pigment epithelium: An important player of retinal disorders and regeneration. Exp. Eye Res.123:107-114. DOI: 10.1016/j.exer.2013.07.009
  16. Mizuno, A., Yasumuro, H., Yoshikawa, T., Inami, W. and Chiba, C*. (2012) MEK-ERK signaling in adult newt retinal pigment epithelium cells is strengthened immediately after surgical induction of retinal regeneration. Neurosci. Lett. 523: 39-44. DOI: 10.1016/j.neulet.2012.06.037
  17. Chiba, C*., Yamada, S., Tanaka, H., Inae-Chiba, M., Miura, T., Casco-Robles, M.M., Yoshikawa, T., Inami, W., Mizuno, A., Islam, MD. R., Han, W., Yasumuro, H., Matsumoto, M. and Takayanagi, M. (2012) Metamorphosis inhibition: an alternative rearing protocol for the newt Cynops pyrrhogaster. Zool. Sci. 29: 293-298. DOI: 10.2108/zsj.29.293
  18. Yoshikawa, T., Mizuno, A., Yasumuro, H., Inami, W., Vergara, M.N., Del Rio-Tsonis, K. and Chiba, C*. (2012) MEK-ERK and heparin-susceptible signaling pathways are involved in cell-cycle entry of the wound edge retinal pigment epithelium cells in the adult newt. Pigment Cell Melanoma Res. 25: 66-82. DOI: 10.1111/j.1755-148X.2011.00935.x
  19. Casco-Robles, M.M., Yamada, S., Miura, T., Nakamura, K., Haynes, T., Maki, N., Del Rio-Tsonis, K., Tsonis, P.A. and Chiba, C.* (2011) Expressing exogenous genes in newts by transgenesis. Nature Protocols 6: 600-608. DOI: 10.1038/nprot.2011.334
  20. Tsonis, P.A.*, Haynes, T., Maki, N., Nakamura, K., Casco-Robles, M.M., Yamada, S., Miura, T., Chiba, C. and Del Rio-Tsonis, K. (2011) Controlling gene loss of function in newts with emphasis on lens regeneration. Nature Protocols 6: 593-599. DOI: 10.1038/nprot.2011.341
  21. Casco-Robles, M.M., Yamada, S., Miura, T. and Chiba, C.* (2010) Simple and efficient transgenesis with I-SceI meganuclease in the newt, Cynops pyrrhogaster. Dev. Dyn. 239: 3275-3284. DOI: 10.1002/dvdy.22463
  22. Kaneko, J. and Chiba, C.* (2009) Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt. Neurosci. Lett. 450: 252-257. DOI: 10.1016/j.neulet.2008.11.031
  23. Susaki, K., Kaneko, J., Yamano, Y., Nakamura, K., Inami, W., Yoshikawa, T., Ozawa, Y., Shibata, S., Matsuzaki, O., Okano, H. and Chiba, C.* (2009) Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp. Eye Res. 88: 347-355. DOI: 10.1016/j.exer.2008.06.019
  24. Susaki, K., Chiba, C.* (2007) MEK mediates in vitro neural transdifferentiation of the adult newt retinal pigment epithelium cells: Is FGF2 an induction factor? Pigment Cell Res. 20: 364-379. DOI: 10.1111/j.1600-0749.2007.00407.x
  25. Nakamura, K., Chiba, C.* (2007) Evidence for Notch signaling involvement in retinal regeneration of adult newt. Brain Res.1136: 28-42. DOI: 10.1016/j.brainres.2006.12.032
  26. Chiba, C.*, Hoshino, A., Nakamura, K., Susaki, K., Yamano, Y., Kaneko, Y., Kuwata, O., Maruo, F. and Saito, T. (2006) Visual cycle protein RPE65 persists in new retinal cells during retinal regeneration of adult newt. J. Comp. Neurol. 495: 391-407. DOI: 10.1002/cne.20880
  27. Chiba, C.*, Hanako, Oi., Saito, T. (2005) Changes in somatic sodium currents of ganglion cells during retinal regeneration in the adult newt. Dev. Brain Res. 154: 25-34. DOI: 10.1016/j.devbrainres.2004.09.011
  28. Chiba, C.*, Nakamura, K., Unno, S., Saito, T. (2004) Intraocular implantation of DNA-transfected retinal pigment epithelium cells: a new approach for analyzing molecular functions in the newt retinal regeneration. Neurosci. Lett. 368: 171-175. DOI: 10.1016/j.neulet.2004.07.009
  29. Oi, H., Chiba, C. and Saito, T.* (2003) A decay of gap junctions associated with ganglion cell differentiationduring retinal regeneration of the adult newt. Vis. Res. 43:2847-2859. DOI: 10.1016/j.visres.2003.07.006
  30. Oi, H., Chiba, C. and Saito, T.* (2003) The appearance and maturation of excitatory and inhibitory neurotransmitter sensitivity during retinal regeneration of the adult newt. Neurosci. Res. 47: 117-129. DOI: 10.1016/S0168-0102(03)00190-1
  31. Tamalu, F., Chiba, C. and Saito, T.* (2001) Gap junctional coupling between multipotent progenitor cells at the retinal margin of adult goldfish. J. Neurobiol.48: 204-214. DOI: 10.1002/neu.1051
  32. Tamalu, F., Chiba, C., Ishida, A.T. and Saito, T.* (2000) Functional differentiation of ganglion cells from multipotent progenitor cells in sliced retina of adult goldfish. J. Comp. Neurol. 419: 297-305. DOI: 10.1002/(SICI)1096-9861(20000410)419:3<297::AID-CNE3>3.0.CO;2-X
  33. Chiba, C.* and Saito, T. (2000) Gap junctional coupling between progenitor cells of regenerating retina in the adult newt. J. Neurobiol. 42: 258-269. DOI: 10.1002/(SICI)1097-4695(20000205)42:2<258::AID-NEU9>3.0.CO;2-F
  34. Chiba, C.* (1998) Appearance of glutamate-like immunoreactivity during retinal regeneration in the adult newt. Brain Res. 785: 171-177. DOI: 10.1016/S0006-8993(97)01427-3
  35. Chiba, C., Matsushima, O., Muneoka, Y. and Saito, T.* (1997) Time course of appearance of GABA and GABA receptors during retinal regeneration in the adult newt. Dev. Brain Res. 98: 204-210. DOI: 10.1016/S0165-3806(96)00195-2
  36. Teranishi, H., Takahashi, T.,Ohtani, M., Ando, M., Muneoka, Y.*, Chiba, C., Saito, T., Takao T. and Shimonishi, Y. (1996) Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster. II. Four VIP-related peptides and two neurotensin-related peptides. Peptide Chemistry 1995 (edited by N. Nishi) 177-180. Out of Stock
  37. Teranishi, H., Muneoka, Y.*, Uesaka, T., Ando, M., Chiba, C., Saito, T., Takao, T., Shimonishi, Y., Minakata H. and Nomoto, K.(1996) Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster. I. A C-type natriuretic peptide (CNP). Peptide Chemistry 1995 (edited by N. Nishi) 173-176. Out of Stock
  38. Chiba, C., Sakai, H., Kaneko, Y. and Saito, T.* (1995) Concanavalin A promotes regeneration of processes of isolated ganglion cells from the adult newt retina. Zool. Sci.12: 741-747.
  39. Chiba, C. and Saito, T.* (1995) Development of responses to excitatory and inhibitory amino acids in spiking cells during retinal regeneration in the adult newt. Jpn. J. Physiol.45: 869-887. DOI: http://doi.org/10.2170/jjphysiol.45.869
  40. Chiba, C. and Saito, T.* (1995) Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina. Jpn. J. Physiol.45: 849-867. DOI: http://doi.org/10.2170/jjphysiol.45.849
  41. Tazaki, K.* and Chiba, C. (1994) Glutamate, acetyl-choline, and γ-aminobutyric acid as transmitters in the pyloric system of the stomatogastric ganglion of a stomatopod, Squilla oratoria. J. Comp. Physiol. A 175: 487-504. DOI: 10.1007/BF00199256
  42. Chiba, C. and Saito, T.* (1994) APB (2-amino-4- phosphonobutyric acid) activates a chloride conductance in ganglion cells isolated from newt retina. NeuroReport 5:489-492.
  43. Tazaki, K.* and Chiba, C. (1993) Cellular properties and modulation of the stomatogastric ganglion neurons of a stomatopod, Squilla oratoria. J. Comp. Physiol. A 173: 85-101. DOI: 10.1007/BF00209621
  44. Kaneko, Y., Sakai, H., Chiba, C. and Saito, T.* (1993) Development of voltage-gated currents in newt retinal neuroblasts in culture. NeuroReport 4: 775-778.
  45. Chiba, C. and Tazaki, K.* (1992) Glutamatergic motoneurons in the stomatogastric ganglion of the mantis shrimp Squilla oratoria. J. Comp. Physiol. A 170:773-786. DOI: 10.1007/BF00198988
  46. Tazaki, K. and Chiba, C. (1991) Mechanisms underlying burst generation of the pyloric muscle in the mantis shrimp, Squilla oratoria. J. Comp. Physiol. A 169:37-750. DOI: 10.1007/BF00194902


Publications in Japanese
日本語論文

  1. 千葉親文、松島治、宗岡洋二郎、斎藤建彦* (1996)「イモリ網膜再生過程におけるGABAとその受容体の発現の時間経過」 病態研究(A-1) pp. 13-16
  2. 千葉親文、斎藤建彦* (1995)「イモリ網膜再生過程における神経節細胞のアミノ酸受容体の発現」 病態研究(A-3) pp.15-17


Doctoral dissertation
学位論文

  Chiba, C. (1995) Amino acid responses in solitary spiking cells during retinal regeneration in the adult newt, Cynops pyrrhogaster. University of Tsukuba. 筑波大学


Books
書籍

  1. 千葉親文* イモリ幼生期と変態後の筋再生メカニズムの違い、pp. 21-26、「特集 筋肉研究の最前線」 CLINICAL CALCIUM、医薬ジャーナル社、2017年3月号(Vol. 27 No.3)、全144ページ
  2. 千葉親文*、アカハライモリ、pp103-109、「研究者が教える動物飼育 第3巻-ウニ,ナマコから脊椎動物へ-」(日本比較生理生化学会編)、共立出版、2012、全194ページ
  3. Chiba, C.* and Mitashov, V. I. (2007) Cellular and molecular events in the adult newt retinal regeneration. In: Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: from Fish to Human. Chiba, C. (Ed.) India, Research Signpost, pp. 15-33.
  4. Chiba, C (Ed.) Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: from Fish to Human. India, Research Signpost, 2007. ISBN: 978-81-308-0200-8.
  5. Saito, T.*, Oi, H., Umino, Y., Fukutomi, A., Chiba, C. and Kuwata, O. (2003) Spatiotemporal changes in gap junctional communication during retinal regeneration of adult newt.The Neural Basis of Early Vision. A.Kaneko (Ed.) Tokyo, Springer, p. 64.
  6. Chiba, C.*, Nakamura, K., Kikuchi, Y., Susaki, K.and Saito, T. (2003) Genes involved in the retinal development are also expressed in the retinal regeneration. The Neural Basis of Early Vision. A.Kaneko (Ed.) Tokyo, Springer, p. 150.
  7. 斎藤建彦*千葉親文 (2003) 「イモリ網膜再生のメカニズム」 神経眼科 20巻 3号 (別冊)pp. 281-289
  8. 斎藤建彦*千葉親文 (2002)「網膜の再生過程における神経細胞の機能分化」 Molecular Medicine 36巻(別冊) pp. 8-18

細胞移植ではない再生の研究②
Newton 10月号 pp.66-67 (2017)



挑む

イモリで探る体の組織再生のしくみ
日経サイエンス 45巻第3号 pp.10-13 (2015)



研究室の小さな生きものたち
イモリ 「くわれっと雷が鳴るまで離はなさねぞ!」 
実験医学 17巻 17号 pp.2332 (1999)