Peer-reviewed publications
査読付論文

  1. Casco-Robles, M.M.*, Echigoya, T., Shimazaki, T., Murakami, Y., Hirano, M., Maruo, F., Mizuno, S., Takahashi, S. and Chiba, C.* (2025) One-step Cre-loxP organism creation by TAx9. Communications Biology 8: 340. DOI: 10.1038/s42003-025-07759-9
  2. Shiga, S., Murakami, Y., Wang, Z., Ando, R., Casco-Robles, M.M., Maruo, F., Toyama, F.* and Chiba, C.* (2024) An adult myogenic cell line of the Japanese fire-bellied newt Cynops pyrrhogaster. Scientific Reports 14: 30041. DOI: https://doi.org/10.1038/s41598-024-81899-6
  3. Casco-Robles, M.M.*, Ikeda, R. Maruo, F. and Chiba, C. (2024) Development of a ZRS reporter system for the newt (Cynops pyrrhogaster) during terrestrial limb regeneration. Biomedicines 12: 2505. DOI: https://doi.org/10.3390/biomedicines12112505
  4. Banda, C.H, Shiraishi, M., Mitsui, K., Okada, Y., Danno, K., Ishiura, R., Maemura, K., Chiba, C., Mizoguchi, A., Imanaka-Yoshida, K., Maruyama, K., Narushima, M.* (2023) Structural and functional analysis of the newt lymphatic system. Scientific Reports 13: 6902. DOI: https://doi.org/10.1038/s41598-023-34169-w
  5. Chen, X., Ando, R., Casco-Robles, R.M., Casco-Robles, M.M., Maruo, F., Obata, S.* and Chiba, C.* (2022) Newtic1 is a component of globular structures that accumulate along the marginal band of erythrocytes in the limb blastema of adult newt, Cynops pyrrhogaster. Biomedicines 10: 2772. DOI: 10.3390/biomedicines10112772
  6. Yu, Z.Y., Shiga, S., Casco-Robles, M.M., Takeshima, K., Maruo, F. and Chiba, C.* (2022) The latent dedifferentiation capacity of newt limb muscles is unleashed by a combination of metamorphosis and body growth. Scientific Reports 12: 11653. DOI: 10.1038/s41598-022-15879-z
  7. Ishii, T., Takashimizu, I., Casco-Robles, M.M., Taya, Y., Yuzuriha, S., Toyama, F., Maruo, F., Kishi, K.* and Chiba, C.* (2021) Skin wound healing of the adult newt, Cynops pyrrhogaster: A unique re-epithelialization and scarless model. Biomedicines 9: 1892. DOI: 10.3390/biomedicines9121892.
  8. Casco-Robles, M.M., Yasuda, K., Yahata, K., Maruo, F. and Chiba, C.* (2021) Reviewing the effects of skin manipulations on adult newt limb regeneration: Implications for the subcutaneous origin of axial pattern formation. Biomedicines 9: 1426. DOI: 10.3390/biomedicines9101426.
  9. Casco-Robles, R.M., Watanabe, A., Eto, K., Takeshima, K., Obata, S., Kinoshita, T., Ariizumi, T., Nakatani, K., Nakada, T., Tsonis, P.A., Casco-Robles, M.M., Sakurai, K., Yahata, K., Maruo, F., Toyama, F.* and Chiba, C.* (2018) Novel erythrocyte clumps revealed by an orphan gene Newtic1 in circulating blood and regenerating limbs of the adult newt . Scientific Reports 8: 7455. DOI: 10.1038/s41598-018-25867-x.
  10. Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.* (2017) Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster. Toxicon 137: 78-82. DOI: 10.1016/j.toxicon.2017.07.016
  11. Yasumuro, H., Sakurai, K., Toyama, F., Maruo, F. and Chiba, C.* (2017) Implications of a multi-step trigger of retinal regeneration in the adult newt. Biomedicines 5: 25. DOI: 10.3390/biomedicines5020025
  12. Casco-Robles, M.M.*, Islam, M.R., Inami, W., Tanaka, H.V., Kunahong, A., Yasumuro, H., Hanzawa, S., Casco-Robles R.M., Toyama, F., Maruo, F. and Chiba, C.* (2016) Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts. Scientific Reports 6: 33761. DOI: 10.1038/srep333761
  13. Tanaka, H.V., Ng, N.C.Y., Yu, Z.Y., Casco-Robles, M.M., Maruo, F., Tsonis, P.A.* and Chiba, C.* (2016) A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts. Nature Communications. 7: 11069. DOI: 10.1038/ncomms11069
  14. Endo, Y.*, Toyama, F., Chiba, C., Mori, H. and Shoji, K. (2016) Memory Efficient de novo Assembly Algorithm using Disk Streaming of K-mers. Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2016). Vol.3, pp.266-271. ISBN: 978-989-758-170-0.
  15. Inami, W., Islam. M.R., Nakamura, K., Yoshikawa, T., Yasumuro, H., Casco-Robles, M.M., Toyama, F., Maruo, F. and Chiba, C.* (2016) Expression of two classes of Pax6 transcripts in reprogramming retinal pigment epithelium cells of the adult newt. Zoological Science 33: 21-30. DOI: 10.2108/zs150111.
  16. Sousounis, K., Qi, F., Yadav, M.C., Millan, J.L., Toyama, F., Chiba, C., Eguchi, Y., Eguchi, G. and Tsonis, P.A.* (2015) A robust transcriptional program in newts undergoing multiple events of lens regeneration. eLife4: e09594. DOI: 10.7554/eLife.09594.
  17. Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.* (2015) Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS. Toxicon 101: 101-105. DOI: 10.1016/j.toxicon.2015.05.008
  18. Endo, Y.*, Toyama, F., Chiba, C., Mori, H. and Shoji, K. (2015) A memory efficient short read de novo assembly algorithm. IPSJ Transactions on Bioinformatics 8: 2-8. DOI: http://doi.org/10.2197/ipsjtbio.8.2
  19. Casco-Robles, M.M.*, Miura, T. and Chiba, C*. (2015) The newt (Cynops pyrrhogaster) RPE65 promoter: molecular cloning, characterization and functional analysis. Transgenic Res. 24: 463-473. DOI: 10.​1007/​s11248-014-9857-1
  20. Nakamura, K., Islam, M.R., Takayanagi, M., Yasumuro, H., Inami, W., Kunahong, A., Casco-Robles, R.M., Toyama, F*. and Chiba, C*. (2014) A transcriptome for the study of early processes of retinal regeneration in the adult newt, Cynops pyrrhogaster. PLoS One 9: e109831. DOI: 10.1371/journal.pone.0109831
  21. Islam, M.R., Nakamura, K., Casco-Robles, M.M., Kunahong, A., Inami, W., Toyama, F., Maruo, F. and Chiba, C*. (2014) The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration. Scientific Reports 4: 6043. DOI: 10.1038/srep06043
  22. Endo, Y., Toyama, F*., Chiba, C., Mori, H. and Shoji, K. (2014) De novo short read assembly algorithm with low memory usage. Proceeding of the International Conference on Bioinformatics Models, Methods and Algorithms. 215-220. DOI: 10.5220/0004881002150220
  23. Chiba, C*. (2014) The retinal pigment epithelium: An important player of retinal disorders and regeneration. Exp. Eye Res.123:107-114. DOI: 10.1016/j.exer.2013.07.009
  24. Mizuno, A., Yasumuro, H., Yoshikawa, T., Inami, W. and Chiba, C*. (2012) MEK-ERK signaling in adult newt retinal pigment epithelium cells is strengthened immediately after surgical induction of retinal regeneration. Neurosci. Lett. 523: 39-44. DOI: 10.1016/j.neulet.2012.06.037
  25. Chiba, C*., Yamada, S., Tanaka, H., Inae-Chiba, M., Miura, T., Casco-Robles, M.M., Yoshikawa, T., Inami, W., Mizuno, A., Islam, MD. R., Han, W., Yasumuro, H., Matsumoto, M. and Takayanagi, M. (2012) Metamorphosis inhibition: an alternative rearing protocol for the newt Cynops pyrrhogaster. Zool. Sci. 29: 293-298. DOI: 10.2108/zsj.29.293
  26. Yoshikawa, T., Mizuno, A., Yasumuro, H., Inami, W., Vergara, M.N., Del Rio-Tsonis, K. and Chiba, C*. (2012) MEK-ERK and heparin-susceptible signaling pathways are involved in cell-cycle entry of the wound edge retinal pigment epithelium cells in the adult newt. Pigment Cell Melanoma Res. 25: 66-82. DOI: 10.1111/j.1755-148X.2011.00935.x
  27. Casco-Robles, M.M., Yamada, S., Miura, T., Nakamura, K., Haynes, T., Maki, N., Del Rio-Tsonis, K., Tsonis, P.A. and Chiba, C.* (2011) Expressing exogenous genes in newts by transgenesis. Nature Protocols 6: 600-608. DOI: 10.1038/nprot.2011.334
  28. Tsonis, P.A.*, Haynes, T., Maki, N., Nakamura, K., Casco-Robles, M.M., Yamada, S., Miura, T., Chiba, C. and Del Rio-Tsonis, K. (2011) Controlling gene loss of function in newts with emphasis on lens regeneration. Nature Protocols 6: 593-599. DOI: 10.1038/nprot.2011.341
  29. Casco-Robles, M.M., Yamada, S., Miura, T. and Chiba, C.* (2010) Simple and efficient transgenesis with I-SceI meganuclease in the newt, Cynops pyrrhogaster. Dev. Dyn. 239: 3275-3284. DOI: 10.1002/dvdy.22463
  30. Kaneko, J. and Chiba, C.* (2009) Immunohistochemical analysis of Musashi-1 expression during retinal regeneration of adult newt. Neurosci. Lett. 450: 252-257. DOI: 10.1016/j.neulet.2008.11.031
  31. Susaki, K., Kaneko, J., Yamano, Y., Nakamura, K., Inami, W., Yoshikawa, T., Ozawa, Y., Shibata, S., Matsuzaki, O., Okano, H. and Chiba, C.* (2009) Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors. Exp. Eye Res. 88: 347-355. DOI: 10.1016/j.exer.2008.06.019
  32. Susaki, K., Chiba, C.* (2007) MEK mediates in vitro neural transdifferentiation of the adult newt retinal pigment epithelium cells: Is FGF2 an induction factor? Pigment Cell Res. 20: 364-379. DOI: 10.1111/j.1600-0749.2007.00407.x
  33. Nakamura, K., Chiba, C.* (2007) Evidence for Notch signaling involvement in retinal regeneration of adult newt. Brain Res.1136: 28-42. DOI: 10.1016/j.brainres.2006.12.032
  34. Chiba, C.*, Hoshino, A., Nakamura, K., Susaki, K., Yamano, Y., Kaneko, Y., Kuwata, O., Maruo, F. and Saito, T. (2006) Visual cycle protein RPE65 persists in new retinal cells during retinal regeneration of adult newt. J. Comp. Neurol. 495: 391-407. DOI: 10.1002/cne.20880
  35. Chiba, C.*, Hanako, Oi., Saito, T. (2005) Changes in somatic sodium currents of ganglion cells during retinal regeneration in the adult newt. Dev. Brain Res. 154: 25-34. DOI: 10.1016/j.devbrainres.2004.09.011
  36. Chiba, C.*, Nakamura, K., Unno, S., Saito, T. (2004) Intraocular implantation of DNA-transfected retinal pigment epithelium cells: a new approach for analyzing molecular functions in the newt retinal regeneration. Neurosci. Lett. 368: 171-175. DOI: 10.1016/j.neulet.2004.07.009
  37. Oi, H., Chiba, C. and Saito, T.* (2003) A decay of gap junctions associated with ganglion cell differentiationduring retinal regeneration of the adult newt. Vis. Res. 43:2847-2859. DOI: 10.1016/j.visres.2003.07.006
  38. Oi, H., Chiba, C. and Saito, T.* (2003) The appearance and maturation of excitatory and inhibitory neurotransmitter sensitivity during retinal regeneration of the adult newt. Neurosci. Res. 47: 117-129. DOI: 10.1016/S0168-0102(03)00190-1
  39. Tamalu, F., Chiba, C. and Saito, T.* (2001) Gap junctional coupling between multipotent progenitor cells at the retinal margin of adult goldfish. J. Neurobiol.48: 204-214. DOI: 10.1002/neu.1051
  40. Tamalu, F., Chiba, C., Ishida, A.T. and Saito, T.* (2000) Functional differentiation of ganglion cells from multipotent progenitor cells in sliced retina of adult goldfish. J. Comp. Neurol. 419: 297-305. DOI: 10.1002/(SICI)1096-9861(20000410)419:3<297::AID-CNE3>3.0.CO;2-X
  41. Chiba, C.* and Saito, T. (2000) Gap junctional coupling between progenitor cells of regenerating retina in the adult newt. J. Neurobiol. 42: 258-269. DOI: 10.1002/(SICI)1097-4695(20000205)42:2<258::AID-NEU9>3.0.CO;2-F
  42. Chiba, C.* (1998) Appearance of glutamate-like immunoreactivity during retinal regeneration in the adult newt. Brain Res. 785: 171-177. DOI: 10.1016/S0006-8993(97)01427-3
  43. Chiba, C., Matsushima, O., Muneoka, Y. and Saito, T.* (1997) Time course of appearance of GABA and GABA receptors during retinal regeneration in the adult newt. Dev. Brain Res. 98: 204-210. DOI: 10.1016/S0165-3806(96)00195-2
  44. Teranishi, H., Takahashi, T.,Ohtani, M., Ando, M., Muneoka, Y.*, Chiba, C., Saito, T., Takao T. and Shimonishi, Y. (1996) Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster. II. Four VIP-related peptides and two neurotensin-related peptides. Peptide Chemistry 1995 (edited by N. Nishi) 177-180. Out of Stock
  45. Teranishi, H., Muneoka, Y.*, Uesaka, T., Ando, M., Chiba, C., Saito, T., Takao, T., Shimonishi, Y., Minakata H. and Nomoto, K.(1996) Structure and action of bioactive peptides isolated from the newt, Cynops pyrrhogaster. I. A C-type natriuretic peptide (CNP). Peptide Chemistry 1995 (edited by N. Nishi) 173-176. Out of Stock
  46. Chiba, C., Sakai, H., Kaneko, Y. and Saito, T.* (1995) Concanavalin A promotes regeneration of processes of isolated ganglion cells from the adult newt retina. Zool. Sci.12: 741-747.
  47. Chiba, C. and Saito, T.* (1995) Development of responses to excitatory and inhibitory amino acids in spiking cells during retinal regeneration in the adult newt. Jpn. J. Physiol.45: 869-887. DOI: http://doi.org/10.2170/jjphysiol.45.869
  48. Chiba, C. and Saito, T.* (1995) Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina. Jpn. J. Physiol.45: 849-867. DOI: http://doi.org/10.2170/jjphysiol.45.849
  49. Tazaki, K.* and Chiba, C. (1994) Glutamate, acetyl-choline, and γ-aminobutyric acid as transmitters in the pyloric system of the stomatogastric ganglion of a stomatopod, Squilla oratoria. J. Comp. Physiol. A 175: 487-504. DOI: 10.1007/BF00199256
  50. Chiba, C. and Saito, T.* (1994) APB　(2-amino-4- phosphonobutyric acid) activates a chloride conductance in ganglion cells isolated from newt retina. NeuroReport 5:489-492.
  51. Tazaki, K.* and Chiba, C. (1993) Cellular properties and modulation of the stomatogastric ganglion neurons of a stomatopod, Squilla oratoria. J. Comp. Physiol. A 173: 85-101. DOI: 10.1007/BF00209621
  52. Kaneko, Y., Sakai, H., Chiba, C. and Saito, T.* (1993) Development of voltage-gated currents in newt retinal neuroblasts in culture. NeuroReport 4: 775-778.
  53. Chiba, C. and Tazaki, K.* (1992) Glutamatergic　motoneurons　in　the　stomatogastric ganglion of the　mantis shrimp Squilla oratoria. J. Comp. Physiol. A 170:773-786. DOI: 10.1007/BF00198988
  54. Tazaki, K. and Chiba, C. (1991) Mechanisms underlying burst generation of the pyloric muscle in the mantis shrimp, Squilla oratoria. J. Comp. Physiol. A 169:37-750. DOI: 10.1007/BF00194902


Publications in Japanese
日本語論文

  1. 千葉親文、松島治、宗岡洋二郎、斎藤建彦*　（１９９６）「イモリ網膜再生過程におけるGABAとその受容体の発現の時間経過」　病態研究（A-1）　pp. 13-16
  2. 千葉親文、斎藤建彦*　（１９９５）「イモリ網膜再生過程における神経節細胞のアミノ酸受容体の発現」　病態研究（A-3） pp.15-17


Doctoral dissertation
学位論文

　　Chiba, C. (1995) Amino acid responses in solitary spiking cells during retinal regeneration in the adult newt, Cynops pyrrhogaster. University of Tsukuba. 筑波大学


Books
書籍

  1. 千葉親文* イモリ幼生期と変態後の筋再生メカニズムの違い、pp. 21-26、「特集　筋肉研究の最前線」　CLINICAL CALCIUM、医薬ジャーナル社、2017年3月号（Vol. 27 No.3）、全144ページ
  2. 千葉親文*、アカハライモリ、pp103-109、「研究者が教える動物飼育　第3巻－ウニ，ナマコから脊椎動物へ－」（日本比較生理生化学会編）、共立出版、2012、全194ページ
  3. Chiba, C.* and Mitashov, V. I. (2007) Cellular and molecular events in the adult newt retinal regeneration. In: Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: from Fish to Human. Chiba, C. (Ed.) India, Research Signpost, pp. 15-33.
  4. Chiba, C (Ed.) Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: from Fish to Human. India, Research Signpost, 2007. ISBN: 978-81-308-0200-8.
  5. Saito, T.*, Oi, H., Umino, Y., Fukutomi, A., Chiba, C. and Kuwata, O. (2003) Spatiotemporal changes in gap junctional communication during retinal regeneration of adult newt.The Neural Basis of Early Vision. A.Kaneko (Ed.) Tokyo, Springer, p. 64.
  6. Chiba, C.*, Nakamura, K., Kikuchi, Y., Susaki, K.and Saito, T. （2003） Genes involved in the retinal development are also expressed in the retinal regeneration. The Neural Basis of Early Vision. A.Kaneko (Ed.) Tokyo, Springer, p. 150.
  7. 斎藤建彦*、千葉親文 (２００３) 「イモリ網膜再生のメカニズム」　神経眼科　20巻　３号　（別冊）pp. 281-289
  8. 斎藤建彦*、千葉親文　（２００２）「網膜の再生過程における神経細胞の機能分化」　Molecular Medicine　36巻（別冊）　pp. 8-18

細胞移植ではない再生の研究②
Newton １０月号　pp.６６-６７　（２０１７）


挑む
イモリで探る体の組織再生のしくみ
日経サイエンス ４５巻第3号 pp.１０-１３ （２０１５）


研究室の小さな生きものたち
イモリ 「くわれっと雷が鳴るまで離はなさねぞ！」　
実験医学 17巻 17号 pp.２３３２ （１９９９）