研究業績PUBLICATION

原著論文 PAPERS 2000年以降のもの。中田・石川研の前身、林・中田研時代の業績を含む

2024年10月 Ishikawa K, Miyata D, Hattori S, Tani H, Kuriyama T, Wei FY, Miyakawa T, Nakada K.
Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene induces brain dysfunction in mice.
Pharmacol Res. 2024 Oct:208:107374. doi: 10.1016/j.phrs.2024.107374.
2022年9月 Ishikawa K, Honma Y, Yoshimi A, Katada S, Ishihara T, Ishihara N, Nakada K.
Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model.
Pharmacol Res. 2022 Sep 27;106467. doi: 10.1016/j.phrs.2022.106467
2022年8月 Tani H, Ishikawa K, Tamashiro H, Ogasawara E, Yasukawa T, Matsuda S, Shimizu A, Kang D, Hayashi JI, Wei FY, Nakada K.
Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.
Nucleic Acids Res. 2022 Aug 24;50(16):9382-9396. doi: 10.1093/nar/gkac699.
2022年2月 Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y.
Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.
Oncol Rep. 2022 Feb;47(2):32. doi: 10.3892/or.2021.8243.
2021年1月 Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
Neuronal degeneration and cognitive impairment can be prevented via normalization of mitochondrial dynamics.
Pharmacol Res. 2021 Jan 163;105246. doi: 10.1016/j.phrs.2020.105246.
2020年9月 Ogasawara E, Nakada K, Ishihara N.
Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.
Pharmacol Res. 2020 Oct 160;105204. doi: 10.1016/j.phrs.2020.105204.
2019年11月 Tani H, Mito T, Velagapudi V, Ishikawa K, Umehara M, Nakada K, Suomalainen A, Hayashi JI.
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Sci Rep. 2019 Nov 5;9(1):16054. doi: 110.1038/s41598-019-52372-6.
2019年3月 Ishikawa K, Kobayashi K, Yamada A, Umehara M, Oka T, Nakada K.
Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells.
PLoS One. 2019 Mar 4;14(3):e0213283. doi: 10.1371/journal.pone.0213283.
2019年2月 Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.
J Neurosci. 2019 Feb 27;39(9):1588-1604. doi: 10.1523/JNEUROSCI.2139-18.2018.

この論文に関連する電子顕微鏡写真が、掲載されたJ Neurosci Vol. 39, Issue 9の表紙に採択されました。
また、この雑誌を発行しているSociety for NeuroscienceのWebページ上でも、画像の一部がバナーとして使用されました。
2018年7月 Mito T, Tani H, Suzuki M, Ishikawa K, Nakada K, Hayashi JI.
Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism.
Exp Anim. 2018 Jul 4. doi: 10.1538/expanim.18-0060.
2018年1月 Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, Hashizume O, Ishikawa K, Nakada K, Hayashi JI.
Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal.
Sci Rep. 2018 Jan 11;8(1):425. doi: 10.1038/s41598-017-18828-3.
2017年11月 Shimizu A, Tani H, Takibuchi G, Ishikawa K, Sakurazawa R, Inoue T, Hashimoto T, Nakada K, Takenaga K, Hayashi JI.
Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.
Biochem Biophys Res Commun. 2017 Nov 4;493(1):252-257. doi: 10.1016/j.bbrc.2017.09.035.
2017年4月 Borna NN, Kishita Y, Ishikawa K, Nakada K, Hayashi JI, Tokuzawa Y, Kohda M, Nyuzuki H, Yamashita-Sugahara Y, Nasu T, Takeda A, Murayama K, Ohtake A, Okazaki Y.
A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy.
J Hum Genet. 2017 Apr;62(5):539-547. doi: 10.1038/jhg.2016.165.
2016年7月 Hayashi JI, Hashizume O, Ishikawa K, Shimizu A.
Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.
Curr Opin Genet Dev. 2016 Jun;38:63-67. doi: 10.1016/j.gde.2016.03.004.
2015年11月 Shimizu A, Enoki S, Ishikawa K, Mito T, Obata K, Nagashima R, Yonekawa H, Nakada K, Hayashi J.
Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.
Biochem Biophys Res Commun. 2015 Nov 27;467(4):1097-102. doi: 10.1016/j.bbrc.2015.09.072.
2015年8月 Hayashi C, Takibuchi G, Shimizu A, Mito T, Ishikawa K, Nakada K, Hayashi J.
A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.
Biochem Biophys Res Commun. 2015 Aug 7;463(4):1021-7. doi: 10.1016/j.bbrc.2015.06.052.
2015年5月 Hashizume O, Ohnishi S, Mito T, Shimizu A, Ishikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J.
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects.
Sci Rep. 2015 May 22;5:10434. doi: 10.1038/srep10434.
2015年3月 Hashizume O, Yamanashi H, Taketo MM, Nakada K, Hayashi J.
A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.
PLoS One. 2015 Mar 4;10(3):e0118561. doi: 10.1371/journal.pone.0118561.
2015年3月 Shimizu A, Mito T, Hashizume O, Yonekawa H, Ishikawa K, Nakada K, Hayashi J.
G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.
Biochem Biophys Res Commun. 2015 Mar 27;459(1):66-70. doi: 10.1016/j.bbrc.2015.02.070.
2015年2月 Takahashi T, Yamamoto M, Amikura K, Kato K, Serizawa T, Serizawa K, Akazawa D, Aoki T, Kawai K, Ogasawara E, Hayashi J, Nakada K, Kainoh M.
A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice.
J Pharmacol Exp Ther. 2015 Feb;352(2):338-45. doi: 10.1124/jpet.114.220673.
2015年1月 Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J.
Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
Biochem Biophys Res Commun. 2015 Jan 24;456(4):933-7. doi: 10.1016/j.bbrc.2014.12.009.
2014年7月 Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi J.
Administration of an antioxidant prevents lymphoma development in transmitochondrial mice overproducing reactive oxygen species.
Exp Anim. 2014;63(4):459-66. Epub 2014 Jul 22.
2014年2月 Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J.
Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene.
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9. doi: 10.1073/pnas.1318109111.
2014年2月 Enoki S, Shimizu A, Hayashi C, Imanishi H, Hashizume O, Mekada K, Suzuki H, Hashimoto T, Nakada K, Hayashi J.
Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.
Exp Anim. 2014;63(1):21-30.
2013年11月 Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J.
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Mitochondrion. 2013 Nov;13(6):881-7. doi: 10.1016/j.mito.2013.07.117.
2013年9月 Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K.
Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice.
G3 (Bethesda). 2013 Sep 4;3(9):1545-52. doi: 10.1534/g3.113.007245.
2013年9月 Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K, Toyama-Sorimachi N, Hayashi J.
Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.
PLoS One. 2013 Sep 30;8(9):e75981. doi: 10.1371/journal.pone.0075981.
2013年2月 Mito T, Kikkawa Y, Shimizu A, Hashizume O, Katada S, Imanishi H, Ota A, Kato Y, Nakada K, Hayashi J.
Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.
PLoS One. 2013;8(2):e55789. doi: 10.1371/journal.pone.0055789.
2012年6月 Hashizume O, Shimizu A, Yokota M, Sugiyama A, Nakada K, Miyoshi H, Itami M, Ohira M, Nagase H, Takenaga K, Hayashi J.
Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development.
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10528-33. doi: 10.1073/pnas.1202367109.
2012年4月 Yamaguchi J, Nishiyama S, Shimanuki M, Ono T, Sato A, Nakada K, Hayashi J, Yonekawa H, Shitara H.
Comprehensive application of an mtDsRed2-Tg mouse strain for mitochondrial imaging.
Transgenic Res. 2012 Apr;21(2):439-47. doi: 10.1007/s11248-011-9539-1.
2011年10月 Nakada K, Hayashi J.
Transmitochondrial mice as models for mitochondrial DNA-based diseases.
Exp Anim. 2011;60(5):421-31.
2011年8月 Imanishi H, Hattori K, Wada R, Ishikawa K, Fukuda S, Takenaga K, Nakada K, Hayashi J.
Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.
PLoS One. 2011;6(8):e23401. doi: 10.1371/journal.pone.0023401.
2011年7月 Imanishi H, Yokota M, Mori M, Shimizu A, Nakada K, Hayashi J.
Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8.
Exp Anim. 2011;60(4):397-404.
2010年10月 Ishikawa K, Toyama-Sorimachi N, Nakada K, Morimoto M, Imanishi H, Yoshizaki M, Sasawatari S, Niikura M, Takenaga K, Yonekawa H, Hayashi J.
The innate immune system in host mice targets cells with allogenic mitochondrial DNA.
J Exp Med. 2010 Oct 25;207(11):2297-305. doi: 10.1084/jem.20092296.
2010年9月 Yokota M, Shitara H, Hashizume O, Ishikawa K, Nakada K, Ishii R, Taya C, Takenaga K, Yonekawa H, Hayashi J.
Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells.
FEBS Lett. 2010 Sep 24;584(18):3943-8. doi: 10.1016/j.febslet.2010.07.048.
2010年8月 Nishiyama S, Shitara H, Nakada K, Ono T, Sato A, Suzuki H, Ogawa T, Masaki H, Hayashi J, Yonekawa H.
Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system.Biochem Biophys Res Commun. 2010 Oct 8;401(1):26-31. doi: 10.1016/j.bbrc.2010.08.143.
2010年8月 Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H.
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells.
FEBS Lett. 2010 Aug 4;584(15):3402-9. doi: 10.1016/j.febslet.2010.06.036.
2010年8月 Ogasawara E, Nakada K, Hayashi J.
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Hum Mol Genet. 2010 Aug 15;19(16):3179-89. doi: 10.1093/hmg/ddq228.
2009年10月 Nakada K, Sato A, Hayashi J.
Mitochondrial functional complementation in mitochondrial DNA-based diseases.
Int J Biochem Cell Biol. 2009 Oct;41(10):1907-13. doi: 10.1016/j.biocel.2009.05.010.
2009年5月 Sato A, Nakada K, Hayashi J.
Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA.
Biofactors. 2009 Mar-Apr;35(2):130-7. doi: 10.1002/biof.14.
2008年12月 Tanaka D, Nakada K, Takao K, Ogasawara E, Kasahara A, Sato A, Yonekawa H, Miyakawa T, Hayashi J.
Normal mitochondrial respiratory function is essential for spatial remote memory in mice.
Mol Brain. 2008 Dec 16;1:21. doi: 10.1186/1756-6606-1-21.
2008年10月 Ishikawa K, Hashizume O, Koshikawa N, Fukuda S, Nakada K, Takenaga K, Hayashi J.
Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis.
FEBS Lett. 2008 Oct 15;582(23-24):3525-30. doi: 10.1016/j.febslet.2008.09.024.
2008年9月 Ishikawa K, Koshikawa N, Takenaga K, Nakada K, Hayashi J.
Reversible regulation of metastasis by ROS-generating mtDNA mutations.
Mitochondrion. 2008 Sep;8(4):339-44. doi: 10.1016/j.mito.2008.07.006.
2008年5月 Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J.
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
Science. 2008 May 2;320(5876):661-4. doi: 10.1126/science.1156906.
2007年12月 Sato A, Nakada K, Shitara H, Kasahara A, Yonekawa H, Hayashi J.
Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age.
Genetics. 2007 Dec;177(4):2031-7..
2007年5月 IInoue S, Yokota M, Nakada K, Miyoshi H, Hayashi J.
Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation.
FEBS Lett. 2007 May 1;581(9):1910-6.
2007年4月 Yonemura I, Nakada K, Sato A, Hayashi J, Fujita K, Kaneko S, Itaya M.
Direct cloning of full-length mouse mitochondrial DNA using a Bacillus subtilis genome vector.
Gene. 2007 Apr 15;391(1-2):171-7.
2006年10月 Nakada K, Sato A, Yoshida K, Morita T, Tanaka H, Inoue S, Yonekawa H, Hayashi J.
Mitochondria-related male infertility.
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15148-53.
2006年5月 Sato A, Nakada K, Hayashi J.
Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.
Biochim Biophys Acta. 2006 May-Jun;1763(5-6):473-81.
2006年6月 Inoue S, Ishikawa K, Nakada K, Sato A, Miyoshi H, Hayashi J.
Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.
Hum Mol Genet. 2006 Jun 1;15(11):1801-7.
2006年5月 Kasahara A, Ishikawa K, Yamaoka M, Ito M, Watanabe N, Akimoto M, Sato A, Nakada K, Endo H, Suda Y, Aizawa S, Hayashi J.
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.
Hum Mol Genet. 2006 Mar 15;15(6):871-81.
2005年11月 Sato A, Kono T, Nakada K, Ishikawa K, Inoue S, Yonekawa H, Hayashi J.
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16765-70.
2005年7月 Ishikawa K, Kasahara A, Watanabe N, Nakada K, Sato A, Suda Y, Aizawa S, Hayashi J.
Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.
Biochem Biophys Res Commun. 2005 Jul 29;333(2):590-5.
2005年4月 Sato A, Nakada K, Akimoto M, Ishikawa K, Ono T, Shitara H, Yonekawa H, Hayashi J.
Rare creation of recombinant mtDNA haplotypes in mammalian tissues.
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6057-62.
2005年2月 Akimoto M, Niikura M, Ichikawa M, Yonekawa H, Nakada K, Honma Y, Hayashi J.
Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.
Biochem Biophys Res Commun. 2005 Feb 25;327(4):1028-35.
2004年10月 Nakada K, Sato A, Sone H, Kasahara A, Ikeda K, Kagawa Y, Yonekawa H, Hayashi J.
Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice.
Biochem Biophys Res Commun. 2004 Oct 8;323(1):175-84.
2004年8月 Sato A, Nakada K, Shitara H, Yonekawa H, Hayashi J.
In vivo interaction between mitochondria carrying mtDNAs from different mouse species.
Genetics. 2004 Aug;167(4):1855-61.
2004年2月 Chen CS, Matsuoka R, Arai S, Momiyama Y, Murakami H, Kuno SY, Ishikawa K, Nakada K, Tawata M, Hayashi J.
Determination of normal ranges of mitochondrial respiratory activities by mtDNA transfer from 54 Human subjects to mtDNA-less HeLa cells for identification of the pathogenicities of mutated mtDNAs.
J Biochem. 2004 Feb;135(2):237-43.
2004年2月 Ono T, Kasahara Y, Nakada K, Hayashi JI.
Presence of interaction but not complementation between human mtDNAs carrying different mutations within a tRNA(Leu(UUR)) gene.
Biochem Biophys Res Commun. 2004 Feb 20;314(4):1107-12.
2003年8月 Okamaoto M, Ohsato T, Nakada K, Isobe K, Spelbrink JN, Hayashi J, Hamasaki N, Kang D.
Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication.
Curr Genet. 2003 Aug;43(5):364-70.
2002年11月 Takahashi Y, Kako K, Kashiwabara S, Takehara A, Inada Y, Arai H, Nakada K, Kodama H, Hayashi J, Baba T, Munekata E.
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.
Mol Cell Biol. 2002 Nov;22(21):7614-21.
2002年11月 Nakada K, Ono T, Hayashi J.
A novel defense system of mitochondria in mice and human subjects for preventing expression of mitochondrial dysfunction by pathogenic mutant mtDNAs.
Mitochondrion. 2002 Nov;2(1-2):59-70.
2001年12月 Nakada K, Inoue K, Hayashi J.
Mito-mice: animal models for mitochondrial DNA-based diseases.
Semin Cell Dev Biol. 2001 Dec;12(6):459-65.
2001年11月 Nakada K, Inoue K, Chen CS, Nonaka I, Goto Y, Ogura A, Hayashi JI.
Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion.
Biochem Biophys Res Commun. 2001 Nov 9;288(4):901-7.
2001年11月 Nakada K, Inoue K, Hayashi J.
Interaction theory of mammalian mitochondria.
Biochem Biophys Res Commun. 2001 Nov 9;288(4):743-6.
2001年8月 Nakada K, Inoue K, Ono T, Isobe K, Ogura A, Goto YI, Nonaka I, Hayashi JI.
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA.
Nat Med. 2001 Aug;7(8):934-40.
2001年7月 Ono T, Isobe K, Nakada K, Hayashi JI.
Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria.
Nat Genet. 2001 Jul;28(3):272-5.
2001年4月 Yamaoka M, Mikami T, Ono T, Nakada K, Hayashi JI.
Mice with only rat mtDNA are required as models of mitochondrial diseases.
Biochem Biophys Res Commun. 2001 Apr 6;282(3):707-11.
2001年1月 Aomi Y, Chen CS, Nakada K, Ito S, Isobe K, Murakami H, Kuno SY, Tawata M, Matsuoka R, Mizusawa H, Hayashi JI.
Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function.
Biochem Biophys Res Commun. 2001 Jan 12;280(1):265-73.
2000年10月 Inoue K, Nakada K, Ogura A, Isobe K, Goto Y, Nonaka I, Hayashi JI.
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes.
Nat Genet. 2000 Oct;26(2):176-81.

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